TY - ABST

T1 - MRI tracheomalacia (TM) assessment in pediatric patients

AU - Ciet, P.

AU - Wielopolski, P.

AU - Lever, S.

AU - Manniesing, R.

AU - de Bruijne, Marleen

AU - Lequin, M. H.

AU - Tiddens, H. A. W. M.

PY - 2011

Y1 - 2011

N2 - Purpose: TM is an excessive narrowing of the intrathoracic part of the trachea. TM is a common congenital pediatric anomaly, but it’s often not recognized due to its unspecific clinical presentation. The aims of our study are: 1) to develop cine-MRI sequences to visualize central airways in static and dynamic conditions in patients that were able to follow specific breathing manoeuvres;2) to develop post-processing tools for image analysis.Methods and Materials: To date 10 subjects (7 males; 2 adults) were enrolled in the pilot study: mean age 15, (range 6 to 30yrs). Volunteers were trained to perform spirometry controlled breathing maneuvers (peak flow and coughing) using a MRI compatible spirometer. “Static” 13-second breath-hold scans covering the entire thoracic region were acquired at end-inspiration and end-expiration using a 3D GRE with TR/TE=1.2/0.5 ms, alpha = 2, sagittal isotropic volume (2.8) x 3mm3 voxels. “Dynamic” scans were performed with the same parameters but covering only the central thorax (1/3 volume), temporal resolution was 500 ms per volume using the TRICKS. In-house developed software for segmentation and analysis was used.Results: All subjects managed to follow the required breathing maneuvers. Images of central airways during static and dynamic conditions were acquired and could be analyzed. Three out of the 8 children had a TM just above the carina during forced expiration, confirmed by bronchoscopy.Conclusion: This pilot study shows that Dynamic-MRI is feasible in pediatric population and allows avoiding radiation exposure and bronchoscopy for the evaluation of central airway dimensions.

AB - Purpose: TM is an excessive narrowing of the intrathoracic part of the trachea. TM is a common congenital pediatric anomaly, but it’s often not recognized due to its unspecific clinical presentation. The aims of our study are: 1) to develop cine-MRI sequences to visualize central airways in static and dynamic conditions in patients that were able to follow specific breathing manoeuvres;2) to develop post-processing tools for image analysis.Methods and Materials: To date 10 subjects (7 males; 2 adults) were enrolled in the pilot study: mean age 15, (range 6 to 30yrs). Volunteers were trained to perform spirometry controlled breathing maneuvers (peak flow and coughing) using a MRI compatible spirometer. “Static” 13-second breath-hold scans covering the entire thoracic region were acquired at end-inspiration and end-expiration using a 3D GRE with TR/TE=1.2/0.5 ms, alpha = 2, sagittal isotropic volume (2.8) x 3mm3 voxels. “Dynamic” scans were performed with the same parameters but covering only the central thorax (1/3 volume), temporal resolution was 500 ms per volume using the TRICKS. In-house developed software for segmentation and analysis was used.Results: All subjects managed to follow the required breathing maneuvers. Images of central airways during static and dynamic conditions were acquired and could be analyzed. Three out of the 8 children had a TM just above the carina during forced expiration, confirmed by bronchoscopy.Conclusion: This pilot study shows that Dynamic-MRI is feasible in pediatric population and allows avoiding radiation exposure and bronchoscopy for the evaluation of central airway dimensions.

U2 - 10.1594/ecr2011/C-1396

DO - 10.1594/ecr2011/C-1396

M3 - Conference abstract for conference

Y2 - 3 March 2011 through 7 March 2011

ER -